Pulmonary manifestation of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients: initial findings with multidetector computed tomography.
Identifieur interne : 000238 ( Main/Exploration ); précédent : 000237; suivant : 000239Pulmonary manifestation of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients: initial findings with multidetector computed tomography.
Auteurs : A. Laqmani [Allemagne] ; G. Adam ; M. RegierSource :
- Medical principles and practice : international journal of the Kuwait University, Health Science Centre [ 1423-0151 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Allemagne (MeSH), Animaux (MeSH), Facteurs temps (MeSH), Femelle (MeSH), Grippe humaine (diagnostic), Grippe humaine (mortalité), Humains (MeSH), Insuffisance respiratoire (MeSH), Mâle (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (mortalité), Pronostic (MeSH), Sous-type H1N1 du virus de la grippe A (MeSH), Suidae (MeSH), Sujet immunodéprimé (MeSH), Sujet âgé (MeSH), Syndrome de détresse respiratoire de l'adulte (MeSH), Tomodensitométrie multidétecteurs (MeSH), Ventilation artificielle (MeSH), Études rétrospectives (MeSH), Évolution de la maladie (MeSH).
- MESH :
- diagnostic : Grippe humaine, Pneumopathie virale.
- mortalité : Grippe humaine, Pneumopathie virale.
- Adulte, Adulte d'âge moyen, Allemagne, Animaux, Facteurs temps, Femelle, Humains, Insuffisance respiratoire, Mâle, Pronostic, Sous-type H1N1 du virus de la grippe A, Suidae, Sujet immunodéprimé, Sujet âgé, Syndrome de détresse respiratoire de l'adulte, Tomodensitométrie multidétecteurs, Ventilation artificielle, Études rétrospectives, Évolution de la maladie.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Animals (MeSH), Disease Progression (MeSH), Female (MeSH), Germany (MeSH), Humans (MeSH), Immunocompromised Host (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (diagnosis), Influenza, Human (mortality), Male (MeSH), Middle Aged (MeSH), Multidetector Computed Tomography (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (mortality), Prognosis (MeSH), Respiration, Artificial (MeSH), Respiratory Distress Syndrome, Adult (MeSH), Respiratory Insufficiency (MeSH), Retrospective Studies (MeSH), Swine (MeSH), Time Factors (MeSH).
- MESH :
- geographic : Germany.
- diagnosis : Influenza, Human, Pneumonia, Viral.
- mortality : Influenza, Human, Pneumonia, Viral.
- Adult, Aged, Animals, Disease Progression, Female, Humans, Immunocompromised Host, Influenza A Virus, H1N1 Subtype, Male, Middle Aged, Multidetector Computed Tomography, Prognosis, Respiration, Artificial, Respiratory Distress Syndrome, Adult, Respiratory Insufficiency, Retrospective Studies, Swine, Time Factors.
Abstract
OBJECTIVE
To describe initial multidetector computed tomographic (MDCT) findings of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients and to evaluate whether or not identification of certain abnormalities can help predict patients who are at risk for a severe clinical course.
SUBJECTS AND METHODS
This retrospective study included 13 patients with confirmed S-OIV infection suffering from an underlying immunodeficiency or who were receiving immunosuppressive therapy. All patients underwent MDCT of the thorax due to respiratory distress. All data were read by two independent radiologists who described the type and pattern of opacities, distribution and extent of the abnormalities observed. Adverse outcome measures were defined as acute respiratory distress syndrome with the need for mechanical ventilation, extracorporeal membrane oxygenation or death.
RESULTS
MDCT revealed pulmonary manifestations in 12 (92%) of 13 individuals. Six (50%) patients showed an adverse outcome with development of acute respiratory distress syndrome, 4 of these died. The most common findings were ground-glass opacities (10/12; 83%) and pulmonary consolidation (7/12; 58%) predominantly with a bilateral distribution. Reticular pattern and a tree-in-bud appearance were found in 3/12 (25%), respectively. Bilateral opacities with extensive involvement of the lung parenchyma were most predictive of a severe clinical course.
CONCLUSION
The MDCT scan in immunocompromised patients with confirmed S-OIV infection frequently revealed pulmonary abnormalities, which included ground-glass opacities and consolidations. Therefore, prediction of an adverse clinical outcome could be made in patients with MDCT findings demonstrating bilateral extensive consolidations, often combined with ground-glass opacities.
DOI: 10.1159/000338399
PubMed: 22678192
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Laqmani</name><affiliation wicri:level="3"><nlm:affiliation>Center for Radiology and Endoscopy, Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. a.laqmani @ uke.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Radiology and Endoscopy, Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Adam, G" sort="Adam, G" uniqKey="Adam G" first="G" last="Adam">G. Adam</name></author><author><name sortKey="Regier, M" sort="Regier, M" uniqKey="Regier M" first="M" last="Regier">M. Regier</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22678192</idno><idno type="pmid">22678192</idno><idno type="doi">10.1159/000338399</idno><idno type="wicri:Area/Main/Corpus">000241</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000241</idno><idno type="wicri:Area/Main/Curation">000241</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000241</idno><idno type="wicri:Area/Main/Exploration">000241</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pulmonary manifestation of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients: initial findings with multidetector computed tomography.</title><author><name sortKey="Laqmani, A" sort="Laqmani, A" uniqKey="Laqmani A" first="A" last="Laqmani">A. Laqmani</name><affiliation wicri:level="3"><nlm:affiliation>Center for Radiology and Endoscopy, Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. a.laqmani @ uke.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Radiology and Endoscopy, Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Adam, G" sort="Adam, G" uniqKey="Adam G" first="G" last="Adam">G. Adam</name></author><author><name sortKey="Regier, M" sort="Regier, M" uniqKey="Regier M" first="M" last="Regier">M. Regier</name></author></analytic><series><title level="j">Medical principles and practice : international journal of the Kuwait University, Health Science Centre</title><idno type="eISSN">1423-0151</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Animals (MeSH)</term><term>Disease Progression (MeSH)</term><term>Female (MeSH)</term><term>Germany (MeSH)</term><term>Humans (MeSH)</term><term>Immunocompromised Host (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (MeSH)</term><term>Influenza, Human (diagnosis)</term><term>Influenza, Human (mortality)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Multidetector Computed Tomography (MeSH)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (mortality)</term><term>Prognosis (MeSH)</term><term>Respiration, Artificial (MeSH)</term><term>Respiratory Distress Syndrome, Adult (MeSH)</term><term>Respiratory Insufficiency (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Swine (MeSH)</term><term>Time Factors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Allemagne (MeSH)</term><term>Animaux (MeSH)</term><term>Facteurs temps (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (diagnostic)</term><term>Grippe humaine (mortalité)</term><term>Humains (MeSH)</term><term>Insuffisance respiratoire (MeSH)</term><term>Mâle (MeSH)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (mortalité)</term><term>Pronostic (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (MeSH)</term><term>Suidae (MeSH)</term><term>Sujet immunodéprimé (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Syndrome de détresse respiratoire de l'adulte (MeSH)</term><term>Tomodensitométrie multidétecteurs (MeSH)</term><term>Ventilation artificielle (MeSH)</term><term>Études rétrospectives (MeSH)</term><term>Évolution de la maladie (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Grippe humaine</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Animals</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Immunocompromised Host</term><term>Influenza A Virus, H1N1 Subtype</term><term>Male</term><term>Middle Aged</term><term>Multidetector Computed Tomography</term><term>Prognosis</term><term>Respiration, Artificial</term><term>Respiratory Distress Syndrome, Adult</term><term>Respiratory Insufficiency</term><term>Retrospective Studies</term><term>Swine</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Allemagne</term><term>Animaux</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Insuffisance respiratoire</term><term>Mâle</term><term>Pronostic</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Suidae</term><term>Sujet immunodéprimé</term><term>Sujet âgé</term><term>Syndrome de détresse respiratoire de l'adulte</term><term>Tomodensitométrie multidétecteurs</term><term>Ventilation artificielle</term><term>Études rétrospectives</term><term>Évolution de la maladie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To describe initial multidetector computed tomographic (MDCT) findings of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients and to evaluate whether or not identification of certain abnormalities can help predict patients who are at risk for a severe clinical course.</p></div><div type="abstract" xml:lang="en"><p><b>SUBJECTS AND METHODS</b></p><p>This retrospective study included 13 patients with confirmed S-OIV infection suffering from an underlying immunodeficiency or who were receiving immunosuppressive therapy. All patients underwent MDCT of the thorax due to respiratory distress. All data were read by two independent radiologists who described the type and pattern of opacities, distribution and extent of the abnormalities observed. Adverse outcome measures were defined as acute respiratory distress syndrome with the need for mechanical ventilation, extracorporeal membrane oxygenation or death.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>MDCT revealed pulmonary manifestations in 12 (92%) of 13 individuals. Six (50%) patients showed an adverse outcome with development of acute respiratory distress syndrome, 4 of these died. The most common findings were ground-glass opacities (10/12; 83%) and pulmonary consolidation (7/12; 58%) predominantly with a bilateral distribution. Reticular pattern and a tree-in-bud appearance were found in 3/12 (25%), respectively. Bilateral opacities with extensive involvement of the lung parenchyma were most predictive of a severe clinical course.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The MDCT scan in immunocompromised patients with confirmed S-OIV infection frequently revealed pulmonary abnormalities, which included ground-glass opacities and consolidations. Therefore, prediction of an adverse clinical outcome could be made in patients with MDCT findings demonstrating bilateral extensive consolidations, often combined with ground-glass opacities.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22678192</PMID><DateCompleted><Year>2013</Year><Month>04</Month><Day>01</Day></DateCompleted><DateRevised><Year>2012</Year><Month>10</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1423-0151</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>6</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>Medical principles and practice : international journal of the Kuwait University, Health Science Centre</Title><ISOAbbreviation>Med Princ Pract</ISOAbbreviation></Journal><ArticleTitle>Pulmonary manifestation of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients: initial findings with multidetector computed tomography.</ArticleTitle><Pagination><MedlinePgn>548-53</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1159/000338399</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To describe initial multidetector computed tomographic (MDCT) findings of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients and to evaluate whether or not identification of certain abnormalities can help predict patients who are at risk for a severe clinical course.</AbstractText><AbstractText Label="SUBJECTS AND METHODS" NlmCategory="METHODS">This retrospective study included 13 patients with confirmed S-OIV infection suffering from an underlying immunodeficiency or who were receiving immunosuppressive therapy. All patients underwent MDCT of the thorax due to respiratory distress. All data were read by two independent radiologists who described the type and pattern of opacities, distribution and extent of the abnormalities observed. Adverse outcome measures were defined as acute respiratory distress syndrome with the need for mechanical ventilation, extracorporeal membrane oxygenation or death.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">MDCT revealed pulmonary manifestations in 12 (92%) of 13 individuals. Six (50%) patients showed an adverse outcome with development of acute respiratory distress syndrome, 4 of these died. The most common findings were ground-glass opacities (10/12; 83%) and pulmonary consolidation (7/12; 58%) predominantly with a bilateral distribution. Reticular pattern and a tree-in-bud appearance were found in 3/12 (25%), respectively. Bilateral opacities with extensive involvement of the lung parenchyma were most predictive of a severe clinical course.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The MDCT scan in immunocompromised patients with confirmed S-OIV infection frequently revealed pulmonary abnormalities, which included ground-glass opacities and consolidations. Therefore, prediction of an adverse clinical outcome could be made in patients with MDCT findings demonstrating bilateral extensive consolidations, often combined with ground-glass opacities.</AbstractText><CopyrightInformation>Copyright © 2012 S. Karger AG, Basel.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Laqmani</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center for Radiology and Endoscopy, Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. a.laqmani @ uke.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adam</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Regier</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>06</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Med Princ Pract</MedlineTA><NlmUniqueID>8901334</NlmUniqueID><ISSNLinking>1011-7571</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016867" MajorTopicYN="Y">Immunocompromised Host</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D061330" MajorTopicYN="Y">Multidetector Computed Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012131" MajorTopicYN="N">Respiratory Insufficiency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>10</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>03</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>4</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22678192</ArticleId><ArticleId IdType="pii">000338399</ArticleId><ArticleId IdType="doi">10.1159/000338399</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><noCountry><name sortKey="Adam, G" sort="Adam, G" uniqKey="Adam G" first="G" last="Adam">G. Adam</name><name sortKey="Regier, M" sort="Regier, M" uniqKey="Regier M" first="M" last="Regier">M. Regier</name></noCountry><country name="Allemagne"><region name="Hambourg"><name sortKey="Laqmani, A" sort="Laqmani, A" uniqKey="Laqmani A" first="A" last="Laqmani">A. Laqmani</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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